Proteolytic Enzyme Sensors Using an Ion-Sensitive Field Effect Transistor

Hongda Fu, Jun ichi Anzai, Tetsuo Osa, Tadayuki Matsuo

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Two kinds of enzyme sensors were fabricated by chemically immobilizing an enzyme on the gate surface of an ion-sensitive field effect transistor (ISFET). One is a trypsin-membrane/ ISFET sensor, which can measure concentrations of JV-benzoyl-L-arginine ethyl ester in the range from 5 x 10-4to 5 x 10–2m. The other is an a-chymotrypsin-membrane/ISFET sensor, which can measure concentrations of N-acetyl-L-tyrosine ethyl ester solution in the range of 5xl0-4—5 x 10–3m. The response of the sensors was affected markedly by pH and the concentration of the working buffer.

本文言語English
ページ(範囲)1190-1193
ページ数4
ジャーナルChemical and Pharmaceutical Bulletin
36
3
DOI
出版ステータスPublished - 1988

ASJC Scopus subject areas

  • 化学 (全般)
  • 創薬

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