Protecting-group-free total synthesis of (-)-rhazinilam and (-)-rhazinicine using a gold-catalyzed cascade cyclization

Kenji Sugimoto, Kazuki Toyoshima, Shiori Nonaka, Kenta Kotaki, Hirofumi Ueda, Hidetoshi Tokuyama

研究成果: Article査読

79 被引用数 (Scopus)

抄録

'Rhaz'zmatazz: A total synthesis of (-)-rhazinilam and the first asymmetric total synthesis of (-)-rhazinicine were accomplished by using constructing the indolizinone core through the gold-catalyzed cyclization of a fully elaborated linear ynamide. The scope and generality of this cascade reaction for the construction of highly substituted indolizinones were also investigated.

本文言語English
ページ(範囲)7168-7171
ページ数4
ジャーナルAngewandte Chemie - International Edition
52
28
DOI
出版ステータスPublished - 2013 7月 8

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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