PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders

研究成果: Review article査読

9 被引用数 (Scopus)

抄録

Neurodegenerative disorders (NDs) are a group of diseases that cause neural cell damage, leading to motility and/or cognitive dysfunctions. One of the causative agents is misfolded protein aggregates, which are considered as undruggable in terms of conventional tools, such as inhibitors and agonists/antagonists. Indeed, there is currently no FDA-approved drug for the causal treatment of NDs. However, emerging technologies for chemical protein degradation are opening up the possibility of selective elimination of target proteins through physiological protein degradation machineries, which do not depend on the functions of the target proteins. Here, we review recent efforts towards the treatment of NDs using chemical protein degradation technologies, and we briefly discuss the challenges and prospects.

本文言語English
ページ(範囲)3346-3354
ページ数9
ジャーナルAngewandte Chemie - International Edition
60
7
DOI
出版ステータスPublished - 2021 2 15

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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