Prosthetic vascular graft infection through a median sternotomy: A multicentre review

Tatsuya Oda, Kenji Minatoya, Junjiro Kobayashi, Yutaka Okita, Hidetoshi Akashi, Hiroyuki Tanaka, Nobuyoshi Kawaharada, Yoshikatsu Saiki, Yukio Kuniyoshi, Kunihiro Nishimura

研究成果: Review article査読

22 被引用数 (Scopus)


OBJECTIVES The aim of this study is to analyse the treatment outcomes of thoracic prosthetic graft infection. METHODS A retrospective chart review was conducted at six hospitals and included the records of 68 patients treated for postoperative prosthetic vascular graft infection (mean age: 62.3 ± 15.1, male 51) from January 2000 to December 2013. The number of patients and the locations of the treated infections were as follows: 13 for aortic root, 16 for ascending aorta, 35 for aortic arch and 4 for aortic root to arch. In-hospital infection occurred in 43 patients and after discharge in 25. RESULTS The mean follow-up time was 2.0 ± 2.3 years. The follow-up rate was 94.1%. The most commonly isolated micro-organism was Staphylococcus aureus (72.1%). Rereplacement of infectious graft was performed in 18 patients (Dacron graft in 12, homograft in 4 and rifampicin-bonded Dacron graft in 2). The overall hospital mortality rate was 35.3% (24/68). The mortality rate among the patients with graft rereplacement was 33.3% (6/18), with pedicled muscle flaps or pedicled omental flaps to cover the graft 25.9% (7/27), with irrigation 55.0% (11/20) and on antibiotic therapy only 0% (0/3). Our multivariate analysis demonstrated that the risk factors of hospital death increased in the absence of pedicled flaps (muscle or omentum) to cover the graft (P = 0.001), age over 55 (P = 0.003), time from onset of initial operation <1 week (P = 0.031) and period before 2008 (P = 0.001). The overall 1-year survival rate was 58.6%. CONCLUSIONS The treatment outcomes of thoracic prosthetic vascular graft infection have not been satisfactory. However, the use of pedicled muscle or omental flaps to cover the graft could improve the outcomes.

ジャーナルInteractive cardiovascular and thoracic surgery
出版ステータスPublished - 2015 6月 1

ASJC Scopus subject areas

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学


「Prosthetic vascular graft infection through a median sternotomy: A multicentre review」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。