Progressive multifocal leukoencephalopathy in a patient with acquired immunodeficiency syndrome (AIDS) manifesting Gerstmann's syndrome

Hiroshi Saito, Hideaki Sakai, Kazuo Fujihara, Kanae Fujihara, Yasuto Itoyama

研究成果: Article

9 引用 (Scopus)

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We reported a case of acquired immunodeficiency syndrome (AIDS) via multiple blood transfusions, who manifested progressive multifocal leukoencephalopathy (PML) about 18 months after the development of AIDS. PML initiated with right hemiparesis, dysphasia, and Gerstmann's syndrome and resulted in death within 2 months after the onset. Neuroimaging examinations revealed white matter lesions mainly in the left posterior parietal lobe. The cortical gray matter also showed abnormal signal intensity. Peripheral CD4+ lymphocyte count was 81/μl. Routine cerebrospinal fluid (CSF) examinations were negative. CSF antibodies against herpes simplex virus, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus as well as serum antibody against toxoplasma gondii were negative. Though autopsy or biopsy of the brain was not performed, JC virus genomes were detected in the CSF sample by a polymerase chain reaction, and their sequencing showed unique alterations of the regulatory regions, characteristic to PML-type JC virus.

元の言語English
ページ(範囲)169-179
ページ数11
ジャーナルTohoku Journal of Experimental Medicine
186
発行部数3
DOI
出版物ステータスPublished - 1998 11

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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