Probing biological systems with near-field optics

Hitoshi Shiku, Christopher W. Hollars, M. Annie Lee, Chad E. Talley, Greg Cooksey, Robert C. Dunn

研究成果: Conference article査読

1 被引用数 (Scopus)


The imaging characteristics of cantilevered NSOM probes operating in a tapping-mode feedback arrangement are discussed and compared to conventional tips employing the shear-force feedback method. Images from a wide range of samples are presented to demonstrate the surface tracking capabilities over both high and low topology samples, in addition to the low fluorescence detection limits possible utilizing the new tips. The results show that the cantilevered tip operating in a tapping-mode arrangement offers enhanced force imaging of the sample topology without compromising the low detection limits or high spatial resolution of the NSOM fluorescence images. The examples discussed here indicate that the new design will be particularly useful for applications involving biological samples that frequently exhibit complex surface topologies.

ジャーナルProceedings of SPIE - The International Society for Optical Engineering
出版ステータスPublished - 1998 12 1
イベントLaser Techniques for Condensed-Phase and Biological Systems - San Jose, CA, United States
継続期間: 1998 1 291998 1 31

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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