Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells

Norihiro Harada, Masafumi Nakayama, Hiroyasu Nakano, Yoshinosuke Fukuchi, Hideo Yagita, Ko Okumura

研究成果: Article査読

158 被引用数 (Scopus)

抄録

TWEAK, a member of the TNF family, induces cell death in some tumor cell lines, but also induces proliferation of endothelial cells and angiogenesis. Recently, fibroblast growth factor-inducible 14 (Fn14) has been identified to be a TWEAK receptor, which may be responsible for the proliferation of endothelial cells and angiogenesis. In this study, we investigated the pro-inflammatory effect of TWEAK on human umbilical vein endothelial cells (HUVEC). We demonstrated that TWEAK could not only induce the proliferation and migration but also upregulate the cell surface expression of adhesion molecules such as ICAM-1 and E-selectin, and induce the secretion of chemokines such as IL-8 and MCP-1 in HUVEC. Moreover, by using an anti-Fn14 mAb that blocks the TWEAK/Fn14 interaction, we demonstrated that Fn14 was constitutively expressed on HUVEC and totally mediated the biological effects of TWEAK on HUVEC. These results indicated that TWEAK could induce pro-inflammatory reactions via Fn14 on HUVEC.

本文言語English
ページ(範囲)488-493
ページ数6
ジャーナルBiochemical and biophysical research communications
299
3
DOI
出版ステータスPublished - 2002

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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