PRL-2 increases Epo and IL-3 responses in hematopoietic cells

Shoko Akiyama, Deepika Dhavan, Taolin Yi

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Dual specificity protein tyrosine phosphatase PRL-2 is overexpressed in pediatric acute myeloid leukemia (AML) and is located at human chromosome 1p35, a region often rearranged or amplified in malignant lymphoma and B-cell chronic lymphocytic leukemia (B-CLL). Little is known of the significance of PRL-2 expression in hematopoietic malignancies. Herein we demonstrated that ectopic expression of PRL-2 in murine pre-B-cell line Baf3ER and mouse bone marrow cells induced key features associated with malignant progression and metastasis. PRL-2-transfected Baf3ER cells had augmented growth responses to hematopoietic growth factors Epo or IL-3 with shortened cell cycle, reduced requirement (5×) for Epo in cell survival, increased cell migration (3×), reduced cell adhesion (5×), and conversion to an immature cell morphology in association with increased expression (3×) of stem cell marker Bmi-1. When transduced into mouse bone marrow cells, PRL-2 increased Epo-induced colony formation (4×) and gave rise to larger colonies. These observations provide evidences implicating PRL-2 as a pathogenic molecule in hematopoietic malignancies and suggest its potential as a novel therapeutic target.

本文言語English
ページ(範囲)209-214
ページ数6
ジャーナルBlood Cells, Molecules, and Diseases
44
4
DOI
出版ステータスPublished - 2010 4
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 分子生物学
  • 血液学
  • 細胞生物学

フィンガープリント

「PRL-2 increases Epo and IL-3 responses in hematopoietic cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル