Primary structure and functional expression from complementary DNA of a brain calcium channel

Yasuo Mori, Thomas Friedrich, Man Suk Kim, Atsushi Mikami, Junichi Nakai, Peter Ruth, Eva Bosse, Franz Hofmann, Veit Flockerzi, Teiichi Furuichi, Katsuhiko Mikoshiba, Keiji Imoto, Tsutomu Tanabe, Shosaku Numa

研究成果: Article査読

700 被引用数 (Scopus)

抄録

The primary structure of a voltage-dependent cal-cium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the α2 and β subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to ω-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.

本文言語English
ページ(範囲)398-402
ページ数5
ジャーナルNature
350
6317
DOI
出版ステータスPublished - 1991 1 1
外部発表はい

ASJC Scopus subject areas

  • 一般

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