Primary malignant hepatic glucagonoma: An autopsy case

Naoko Obi, Takuyuki Katabami, Ryusei Obi, Mieko Odanaka, Kiminobu Sasano, Yasushi Tanaka

研究成果: Article査読

4 被引用数 (Scopus)


A 73-year-old woman was admitted to our department for treatment of diabetes (plasma glucose 289 mg/dl, HbA1C 7.1%, and glycated albumin 34.9%). she displayed the signs and symptoms of glucagonoma syndrome, including necrolytic migratory erythema (Nme), low aminoacidemia, and a marked increase of the serum glucagon level (4,940 pg/ ml). Thus, we suspected a glucagonoma causing secondary diabetes. however, we could not detect any mass in the pancreas or the gastrointestinal tract, and only found a liver lesion resembling a hemangioma. her NME improved markedly after intravenous infusion of amino acids, and her plasma glucose was controlled reasonably well by intensive insulin therapy. however, her general condition deteriorated and she died on day 57 after hospitalization. at autopsy, the only tumor detected was the liver mass. This was a large solid tumor (8x6x5 cm) with a pattern of white and dark brown stripes located in the left lobe, while two white nodules were also found in the right lobe. based on the histopathological and immunohistochemical findings, the liver lesion was shown to be a malignant glucagonoma with intrahepatic metastases. since primary malignant hepatic glucagonoma has not been reported before, we present this extremely rare case of primary malignant glucagonoma of the liver.

ジャーナルendocrine journal
出版ステータスPublished - 2009

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学


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