Prevention of tissue adhesion by a spontaneously formed phospholipid polymer hydrogel

Mizuna Kimura, Tomohiro Konno, Madoka Takai, Noriyuki Ishiyama, Toru Moro, Kazuhiko Ishihara

研究成果: Article査読

3 被引用数 (Scopus)

抄録

We investigated phospholipid polymer hydrogels containing Fe3+ ions (PMA/PMB/Fe hydrogel) for their use as antiadhesive materials in the healing tissues. These hydrogels were prepared from the aqueous solutions of poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-methacrylic acid) (PMA) and poly(MPC-co-n-butyl methacrylate) (PMB). The PMA/PMB hydrogel is formed by the intermolecular interactions between PMA and PMB, and it reversibly dissociates under physiological conditions. The addition of Fe3+ ions could control the gelation time and the dissociation time. Mechanical properties such as the gelation time and viscoelastic properties can be controlled by the FeCL3 concentration. With regard to biocompatibility, no evidence of inflammation was observed in vivo. Therefore, the PMA/PMB/Fe hydrogel has a potential to be used as an antiadhesive material.

本文言語English
ページ(範囲)777-780
ページ数4
ジャーナルKey Engineering Materials
342-343
DOI
出版ステータスPublished - 2007 1 1
外部発表はい

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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