Prevention of Carcinogenicity of Anticancer Drugs by Metallothionein Induction

Masahiko Satoh, Yukihiro Kondo, Masaharu Mita, Ippei Nakagawa, Akira Naganuma, Nobumasa Imura

研究成果: Article査読

56 被引用数 (Scopus)

抄録

We examined the efficacy of metallothionein induction in the prevention of the carcinogenic action of cis-platinum and melphalan administered repeatedly to mice over a relatively long period. The increased pulmonary metallothionein induced by bismuth or zinc compounds during the period of chemotherapy with cis-platinum or melphalan protected the mice from carcinogenesis of these drugs in the lung. These results suggested the efficacy of metallothionein inducers in suppression of carcinogenicity considered as a secondary effect of anticancer agents in cancer chemotherapy.

本文言語English
ページ(範囲)4767-4768
ページ数2
ジャーナルCancer Research
53
20
出版ステータスPublished - 1993 10月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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