Preparation of spherical porous granules composed of rod-shaped hydroxyapatite and evaluation of their protein adsorption properties

Toshiharu Takahashai, Masanobu Kamitakahara, Giichiro Kawachi, Koji Ioku

研究成果: Article査読

9 被引用数 (Scopus)

抄録

The present study examined the possibility of using spherical porous granules of hydroxyapatite (HA, Ca10(PO4) 6(OH)2) composed of rod-shaped particles as the drug delivery system. The granules composed of rod-shaped HA were successfully prepared by an emulsion method and a hydrothermal treatment When the rod-shaped granules were soaked in phosphate buffer salines containing lysozyme chloride or albumin, the granules of rod-shaped HA adsorbed more albumin than lysozyme. On the other hand, the HA granules prepared by a normal sintering method adsorbed little lysozyme chloride or albumin. The HA granules composed of rod-shaped particles are expected to be useful as carriers of negatively charged substances.

本文言語English
ページ(範囲)83-86
ページ数4
ジャーナルKey Engineering Materials
361-363 I
出版ステータスPublished - 2008 1月 1

ASJC Scopus subject areas

  • 材料科学(全般)
  • 材料力学
  • 機械工学

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