Preparation of blood compatible nanoparticles bearing phosphorylcholine group

Kazuhiko Ishihara, Tomohiro Konno, Kimio Kurita, Yasuhiko Iwasaki, Nobuo Nakabayashi

研究成果: Conference article査読

抄録

Water-soluble copolymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and n-butyl methacrylate (BMA) (PMB30W) was synthesized giving attention to the balance of hydrophilicity and hydrophobicity in the copolymer. The characteristics of biodegradable poly(L-lactic acid) (PLA) nanoparticle coated with the PMB30W were studied. The PLA/PMB30W nanoparticles effectively restrained the interaction with the biocomponents. The copolymer improved the blood compatibility of the PLA nanoparticles as a drug carrier. These nanoparticles have strong potential to obtain a long-term circulation in the blood stream.

本文言語English
ページ(範囲)283-284
ページ数2
ジャーナルAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
40
1
出版ステータスPublished - 1999 3 1
外部発表はい
イベントProceedings of the 1999 ACS Anaheim Meeting - Anaheim, CA, USA
継続期間: 1999 3 211999 3 25

ASJC Scopus subject areas

  • ポリマーおよびプラスチック

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