Preparation of a fine powder of 2-deoxy-2-[18F]fluoro-D-glucose suitable for inhalation to diagnose lung diseases by means of PET

Fumiyoshi Ojima, Tatsuo Ido, Toshihiro Takahashi, Jun Hatazawa, Masatoshi Ito, Hidetada Sasaki, Masaru Yanai, Takashi Aikawa, Tamotsu Takishima, Kenji Abiko, Masafumi Amano

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Fine 2-deoxy-2-[18F]fluoro-D-glucose (18FDG) powder was obtained by adding diethyl ether into a methyl alcohol solution of18FDG and other sugar as seed. When micronized particles of sodium N-acetyl-neuraminate (Neu5Ac-Na) were used as seed crystals, particles containing18FDG were obtained and 80% of them were smaller than 10μm in size. More than 60 % of these crystals were 4-6 μm in size. In a preclinical study of forced inhalation in a dog, the18FDG fine powder was mainly distributed in the trachea. The radioactivity in the trachea then increased once and a gradual decrease followed. The radioactivity was transferred into the blood and radioactivity incorporation into the heart was observed. After a normal volunteer inhaled18FDG dry powder aerosol, the radioactivity was found in the respiratory tract and the peripheral area of the lung by means of PET. Absorption and in vivo dynamics of the18FDG were also analysed.

本文言語English
ページ(範囲)143-147
ページ数5
ジャーナルAnnals of Nuclear Medicine
3
3
DOI
出版ステータスPublished - 1989 12

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

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