TY - JOUR
T1 - Prenatal alcohol exposure and adverse fetal growth restriction
T2 - findings from the Japan Environment and Children’s Study
AU - The Japan Environment and Children’s Study Group
AU - Cho, Kazutoshi
AU - Kobayashi, Sumitaka
AU - Araki, Atsuko
AU - Miyashita, Chihiro
AU - Itoh, Sachiko
AU - Saijo, Yasuaki
AU - Ito, Yoshiya
AU - Sengoku, Kazuo
AU - Baba, Tsuyoshi
AU - Minakami, Hisanori
AU - Nakamura, Yuichi
AU - Kishi, Reiko
AU - Kamijima, Michihiro
AU - Yamazaki, Shin
AU - Ohya, Yukihiro
AU - Kishi, Reiko
AU - Yaegashi, Nobuo
AU - Hashimoto, Koichi
AU - Mori, Chisato
AU - Ito, Shuichi
AU - Yamagata, Zentaro
AU - Inadera, Hidekuni
AU - Nakayama, Takeo
AU - Iso, Hiroyasu
AU - Shima, Masayuki
AU - Kurozawa, Youichi
AU - Suganuma, Narufumi
AU - Kusuhara, Koichi
AU - Katoh, Takahiko
N1 - Funding Information:
We thank all the individuals who participated in the Japan Environment and Children’s Study. We express our sincere appreciation to the collaborating hospitals and clinics. We also express our gratitude to the members of staff of the Hokkaido, Miyagi, Fukushima, Chiba, Kanagawa, Koshin, Toyama, Aichi, Kyoto, Osaka, Hyogo, Tottori, Kochi, Fukuoka, and Minami-Kyushu and Okinawa Regional Centers, Program Office, and Medical Support Center for the Japan Environment and Children’s Study (Appendix 1). The Japan Environment and Children’s Study is funded by the operating budget of the Ministry of the Environment, Japan. The findings and conclusions of this article are solely the responsibility of the authors and do not represent the official views of the Ministry of the Environment of the Japanese government.
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.
PY - 2022/7
Y1 - 2022/7
N2 - Backgrounds: Japanese studies on the association between maternal alcohol consumption and fetal growth are few. This study assessed the effect of maternal alcohol consumption on fetal growth. Methods: This prospective birth cohort included 95,761 participants enrolled between January 2011 and March 2014 in the Japan Environment and Children’s Study. Adjusted multiple linear and logistic regression models were used to assess the association between prenatal alcohol consumption and infant birth size. Results: Consumption of a weekly dose of alcohol in the second/third trimester showed a significant negative correlation with standard deviation (SD; Z) scores for body weight, body length, and head circumference at birth, respectively. Consumption of a weekly dose of alcohol during the second/third trimester had a significant positive correlation with incidences of Z-score ≤ −1.5 for birth head circumference. Associations between alcohol consumption in the second/third trimester and Z-score ≤ −1.5 for birth weight or birth length were not significant. Maternal alcohol consumption in the second/third trimester above 5, 20, and 100 g/week affected body weight, body length, and head circumference at birth, respectively. Conclusion: Low-to-moderate alcohol consumption during pregnancy might affect fetal growth. Public health policies for pregnant women are needed to stop alcohol consumption during pregnancy. Impact: This study examined the association between maternal alcohol consumption and fetal growth restriction in 95,761 pregnant Japanese women using the prospective birth cohort.Maternal alcohol consumption in the second/third trimester more than 5, 20, and 100 g/week might affect fetal growth in body weight, body length, and head circumference, respectively.The findings are relevant and important for educating pregnant women on the adverse health effects that prenatal alcohol consumptions have on infants.
AB - Backgrounds: Japanese studies on the association between maternal alcohol consumption and fetal growth are few. This study assessed the effect of maternal alcohol consumption on fetal growth. Methods: This prospective birth cohort included 95,761 participants enrolled between January 2011 and March 2014 in the Japan Environment and Children’s Study. Adjusted multiple linear and logistic regression models were used to assess the association between prenatal alcohol consumption and infant birth size. Results: Consumption of a weekly dose of alcohol in the second/third trimester showed a significant negative correlation with standard deviation (SD; Z) scores for body weight, body length, and head circumference at birth, respectively. Consumption of a weekly dose of alcohol during the second/third trimester had a significant positive correlation with incidences of Z-score ≤ −1.5 for birth head circumference. Associations between alcohol consumption in the second/third trimester and Z-score ≤ −1.5 for birth weight or birth length were not significant. Maternal alcohol consumption in the second/third trimester above 5, 20, and 100 g/week affected body weight, body length, and head circumference at birth, respectively. Conclusion: Low-to-moderate alcohol consumption during pregnancy might affect fetal growth. Public health policies for pregnant women are needed to stop alcohol consumption during pregnancy. Impact: This study examined the association between maternal alcohol consumption and fetal growth restriction in 95,761 pregnant Japanese women using the prospective birth cohort.Maternal alcohol consumption in the second/third trimester more than 5, 20, and 100 g/week might affect fetal growth in body weight, body length, and head circumference, respectively.The findings are relevant and important for educating pregnant women on the adverse health effects that prenatal alcohol consumptions have on infants.
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U2 - 10.1038/s41390-021-01595-3
DO - 10.1038/s41390-021-01595-3
M3 - Article
C2 - 34088984
AN - SCOPUS:85107565655
VL - 92
SP - 291
EP - 298
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 1
ER -
