Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS

Toshio Hattori, Shojiro Ikematsu, Atsushi Koito, Shuzo Matsushita, Yosuke Maeda, Masao Hada, Michio Fujimaki, Kiyoshi Takatsuki

研究成果: Article査読

95 被引用数 (Scopus)

抄録

Glycyrrhizin (GL) at a dose of 400-1600 mg/day (7.2-30.8 mg/kg/day) was administered intravenously for a period of more than a month, on 6 separate occasions, to 3 hemophiliacs with acquired immune deficiency syndrome (AIDS). Human immunodeficiency virus type 1 (HIV-1) p24 antigen was detected at the beginning of 5 of the 6 treatment courses. Viral antigen was not detected at the end of or during 3 of the 5 treatment courses and decreased to a low level following the 2 other courses. These findings suggest that GL might inhibit HIV-1 replication in vivo.

本文言語English
ページ(範囲)255-261
ページ数7
ジャーナルAntiviral Research
11
5-6
DOI
出版ステータスPublished - 1989
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • ウイルス学

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