Predictors of the disappearance of triad symptoms in patients with idiopathic normal pressure hydrocephalus after shunt surgery

Hiroaki Kazui, Etsuro Mori, Shingo Ohkawa, Takaharu Okada, Takeo Kondo, Ryuji Sakakibara, Osamu Ueki, Yoshiyuki Nishio, Kazunari Ishii, Tetsuro Kawaguchi, Masatsune Ishikawa, Masatoshi Takeda

研究成果: Article査読

31 被引用数 (Scopus)

抄録

We identified factors that predict the disappearance of the triad of symptoms (gait disturbance, cognitive impairment and urinary incontinence) of idiopathic normal pressure hydrocephalus (iNPH) following shunt surgery in this study. We classified 71 patients with iNPH into those whose objective symptoms disappeared (disappearance group) or remained (residual group), for each of the triad symptoms 12 months after shunt surgery. Logistic regression analyses were used to identify the predictors of the disappearance of symptoms among 10 variables before shunt surgery (e.g., age, sex, severity of symptoms, Evans index, cerebrospinal fluid (CSF) pressure, CSF stasis on computerized tomographic cisternography, regional cerebral blood flow on single photon emission computed tomography, three kinds of prior diseases). For each of the triad symptoms, mild symptoms before shunt surgery were predictors of the disappearance of the symptom. Young age was also a predictor of the disappearance of gait disturbance. When the analysis was conducted using subscores of the Mini Mental State Examination, a successful visuoconstruction subtest and an absence of hypertension were predictors of the disappearance of cognitive impairment. None of the neuroimaging examinations predicted the disappearance of symptoms after shunt surgery in this study.

本文言語English
ページ(範囲)64-69
ページ数6
ジャーナルJournal of the neurological sciences
328
1-2
DOI
出版ステータスPublished - 2013 5月 15

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学

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