Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression

Yasuhiro Komuro, T. Watanabe, Y. Hosoi, Y. Matsumoto, K. Nakagawa, S. Saito, S. Ishihara, S. Kazama, N. Tsuno, J. Kitayama, N. Suzuki, G. Tsurita, T. Muto, H. Nagawa

研究成果: Article査読

35 被引用数 (Scopus)

抄録

The identification of predictive indicators of radiosensitivity is extremely useful in selecting patients suited for preoperative radiotherapy and avoiding unnecessary preoperative treatment. In this study, we evaluated the possible role of the immunohistochemical expression pattern of p53 and Ku70 protein in determining tumor radiosensitivity in rectal cancer before preoperative irradiation. We examined pretreatment biopsy materials from 111 patients by immunohistochemistry. The expression pattern of p53 and Ku70 was evaluated for association with tumor radiosensitivity, which was defined according to the criteria of the Japanese Research Society for Cancer of the Colon and Rectum. There was a significant correlation between the expression pattern of p53 and tumor radiosensitivity (P=0.045); Ku70 and tumor radiosensitivity (P<0.001); and the combination of p53 and Ku70, and tumor radiosensitivity (P<0.001). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in both p53 and Ku70-positive cases for radioresistance were all superior to those of the group positive for p53 alone. In conclusion the examination of the combination of p53 and Ku70 may predict the radiosensitivity of rectal cancer before preoperative irradiation.

本文言語English
ページ(範囲)223-228
ページ数6
ジャーナルJournal of Experimental and Clinical Cancer Research
22
2
出版ステータスPublished - 2003 6月
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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