Preclinical and clinical evaluation of O-[11C]methyl-L-tyrosine for tumor imaging by positron emission tomography

Kiichi Ishiwata, Hideo Tsukada, Kazuo Kubota, Tadashi Nariai, Norihiro Harada, Kazunori Kawamura, Yuichi Kimura, Keiichi Oda, Ren Iwata, Kenji Ishii

研究成果: Article査読

17 被引用数 (Scopus)

抄録

We performed preclinical and clinical studies of O-[11C]methyl- l-tyrosine, a potential tracer for imaging amino acid transport of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[11C]methyl-l-tyrosine and the acute toxicity and mutagenicity of O-methyl-l-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[11C]methyl-l-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[11C]methyl-l-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated.

本文言語English
ページ(範囲)253-262
ページ数10
ジャーナルNuclear Medicine and Biology
32
3
DOI
出版ステータスPublished - 2005 4月
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 放射線学、核医学およびイメージング
  • 癌研究

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