Potentiation of Procaine-induced Local Sensory Block by Verapamil in Rats

Hideya Ohmori, Hiroshi Iwasaki, Keiichi Omote, Mikito Kawamata, Tomoyuki Kawamata, Masanori Yamauchi, Akiyoshi Namiki

研究成果: Article査読

1 被引用数 (Scopus)


We have studied the effects of calcium-channel blocker, verapamil, on procaine-induced local sensory block. Standardized tail-flick (TF) test was used to investigate the duration and intensity of procaine-induced local conduction block in rats. After obtaining baseline TF latencies (mean; 3.3 sec), two 100-μl of 0.4 % procaine alone, a combination of 0.4 % procaine and verapamil (100 μg, or 200 μ or a large dose of verapamil (200 μg) were injected to the opposite sites of the tail base and TF test was performed every five minutes for 45 minutes. A large dose of verapamil showed no prolongation of TF latencies. The administration of 0.4 % procaine alone produced a significant increase of TF latencies and the peak effect of % MPE (percent maximum possible effect) was demonstrated at 4 minutes after the drug injection (mean % MPE ; 37.0 %). Coadministration of 0.4 % procaine and two doses of verapamil produced significant increases of % MPE in a dose-dependent fashion. It was concluded that sensory block by procaine of the peripheral nerves is potentiated by coadministration of calcium-channel blocker, verapamil.

ジャーナルJapanese Journal of Anesthesiology
出版ステータスPublished - 1996 12 1

ASJC Scopus subject areas

  • 麻酔学および疼痛医療


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