Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: Role of blood cell-associated lysophospholipase D activity of autotaxin

Yoshibumi Shimizu, Yoshiyuki Morikawa, Shinichi Okudaira, Shigenobu Kimoto, Tamotsu Tanaka, Junken Aoki, Akira Tokumura

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Itching and infiltration of immune cells are important hallmarks of atopic dermatitis (AD). Although various studies have focused on peripheral mediator-mediated mechanisms, systemic mediator-mediated mechanisms are also important in the pathogenesis and development of AD. Herein, we found that intradermal injection of lysophosphatidic acid (LPA), a bioactive phospholipid, induces scratching responses by Institute of Cancer Research mice through LPA1 receptor- and opioid μ receptor-mediating mechanisms, indicating its potential as a pruritogen. The circulating level of LPA in Naruto Research Institute Otsuka Atrichia mice, a systemic AD model, with severe scratching was found to be higher than that of control BALB/c mice, probably because of the increased lysophospholipase D activity of autotaxin (ATX) in the blood (mainly membrane associated) rather than in plasma (soluble). Heparan sulfate proteoglycan was shown to be involved in the association of ATX with blood cells. The sequestration of ATX protein on the blood cells by heparan sulfate proteoglycan may accelerate the transport of LPA to the local apical surface of vascular endothelium with LPA receptors, promoting the hyperpermeability of venules and the pathological uptake of immune cells, aggravating lesion progression and itching in Naruto Research Institute Otsuka Atrichia mice.

本文言語English
ページ(範囲)1593-1603
ページ数11
ジャーナルAmerican Journal of Pathology
184
5
DOI
出版ステータスPublished - 2014 5

ASJC Scopus subject areas

  • 病理学および法医学

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