Potential bile acid metabolites. 19. The epimeric 3α,6,7β-trihydroxy-and 3α,6,7β,12α-tetrahydroxy-5α-cholanoic acids

Takashi Iida, Shinji Nishida, Frederic C. Chang, Toshifumi Niwa, Junichi Goto, Toshio Nambara

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Syntheses by a new procedure of the known 3α,6α,7β- and 3α,6β,7β-trihydroxy-5α-cholanoic acids, and of the once-reported analog 3α,6α,7β,12α-, as well as the new 3α,6β,7β,12α-tetrahydroxy-5α-cholanoic acids, are described. Key intermediates of the syntheses are the 6-oxo-7β-ols of the respective 5α-cholanoic acids (and their methyl esters) prepared by allomerization at C-5 of appropriate 6-bromo-7-oxo derivatives of the corresponding 5β-acids. Successful reduction of the 6,7-ketols to the desired products depended on the proper choice of reagents, either Zn(BH4)2 or Li/NH3/MeOH. (Steroids 58:148-152, 1993).

本文言語English
ページ(範囲)148-152
ページ数5
ジャーナルSteroids
58
4
DOI
出版ステータスPublished - 1993 4

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学
  • 薬理学
  • 臨床生化学
  • 有機化学

フィンガープリント

「Potential bile acid metabolites. 19. The epimeric 3α,6,7β-trihydroxy-and 3α,6,7β,12α-tetrahydroxy-5α-cholanoic acids」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル