Postural and gait disturbance correlated with decreased frontal cerebral blood flow in Alzheimer disease

Takashi Nakamura, Kenichi Meguro, Hideki Yamazaki, Hideyuki Okuzumi, Atushi Tanaka, Ayumu Horikawa, Keiichiro Yamaguchi, Naofumi Katsuyama, Masao Nakano, Hiroyuki Arai, Hidetada Sasaki

研究成果: Article査読

72 被引用数 (Scopus)

抄録

In a group of 45 patients with Alzheimer disease (AD) and 15 control subjects, we studied the relationship between parameters showing postural and gait disturbance and regional cerebral blood flow (rCBF) measured with N-isopropyl-p-[123I]iodoamphetamine single photon emission computed tomography at different clinical stages. Patients with AD with mild dementia exhibited only increased postural sway associated with a reduced mean value of rCBF in the cortex. At a moderate stage, the reduced mean values of rCBF in the cortex and in the frontal lobe were associated with increased postural sway and stride length variability and with decreased stride length. At a severe stage, reduced rCBF in the basal ganglia and in the frontal lobe additionally were associated with increased postural sway, double support time, and stride length variability, and with decreased walking speed and stride length. In multiple regression analysis, there was a high contribution by rCBF in the frontal lobe to account for postural and gait disturbance in AD. We propose that impaired frontal lobe circulation is an important factor causing postural and gait disturbance as AD progresses.

本文言語English
ページ(範囲)132-139
ページ数8
ジャーナルAlzheimer Disease and Associated Disorders
11
3
DOI
出版ステータスPublished - 1997 9
外部発表はい

ASJC Scopus subject areas

  • 臨床心理学
  • 老年学
  • 老年医学
  • 精神医学および精神衛生

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