Postprandial increase in the duodenal pH and the effect of intravenous secretin injection on ionic compositions of duodenal fluid and plasma in sheep

K. Katoh, A. Yamazaki, Y. Sasaki, T. Tsuda

    研究成果: Article査読

    抄録

    Testing five castrated male sheep with a pH-electrode inserted into the duodenal digesta through a T-shaped cannula, we found that the pH of the duodenal digesta was significantly increased from 3.11 ± 0.11 to 3.47 ± 0.09 after a meal. Secretin (2.5 CHR U/kg) was intravenously injected to mimic the duodenal pH increase. The administration significantly increased the duodenal digesta pH from 3.32 ± 0.18 to 4.85 ± 0.61, which was accompanied by an increase in sodium concentration, but by a decrease in potassium and chloride concentrations. It also significantly decreased the arterial blood pH from 7.543 ± 0.002 to 7.515 ± 0.008, which was accompanied by a reduced plasma HCO-3 concentration. From these results, we conclude that in sheep, feeding increases the duodenal digesta pH, and the postprandial pH increase in the duodenal fluid would be due to the raised HCO-3 secretion from the gastrointestinal tract.

    本文言語English
    ページ(範囲)995-1000
    ページ数6
    ジャーナルComparative Biochemistry and Physiology -- Part A: Physiology
    109
    4
    DOI
    出版ステータスPublished - 1994 12

    ASJC Scopus subject areas

    • Physiology

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