Postoperative changes of intrahepatic portal veins in biliary atresia-A 3-D reconstruction study

Noriaki Ohuchi, Ryoji Ohi, Tohru Takahashi, Morio Kasai

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Intrahepatic portal veins were reconstructed from serial histologic sections of surgical liver specimens from patients with biliary atresia to explain the pathogenesis of portal hypertension, an important late postoperative complication of this disease. It was found that abnormal intrahepatic vasculature was already notable in an evidently reduced number of portal veins in the second month of age, and this was considered responsible for causing presinusoidal block that gave rise to the elevated resistance to intrahepatic portal flow. Reconstruction also revealed that restoration of ordinary portal structure was expectable if, after successful surgery, a patient was sufficiently protected from cholangitis and there was much room for portal veins to grow without being impeded by inflammatory and/or scarring processes. In contrast, the patients whose condition was complicated by cholangitis was shown to acquire a markedly hypoplastic portal system with apparently reduced vascularity.

本文言語English
ページ(範囲)10-14
ページ数5
ジャーナルJournal of Pediatric Surgery
21
1
DOI
出版ステータスPublished - 1986 1

ASJC Scopus subject areas

  • 外科
  • 小児科学、周産期医学および子どもの健康

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