Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide

Yu Odashima, Keisuke Nakamura, Hiroyo Ikai, Taro Kanno, Luiz Meirelles, Keiichi Sasaki, Yoshimi Niwano

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The purpose of the present study was to evaluate the postantibiotic effect (PAE) of the disinfection treatment by photolysis of H2O2. Postantibiotic effect was induced in Staphylococcus aureus and Streptococcus salivarius by exposing the bacteria to H2O2 at concentrations of 250-1000 mmol/l, laser irradiation at a wavelength of 405 nm, and the combination of both (photolysis of H2O2) for 10-30 seconds. The photolysis of H2O2 induced significantly longer PAE than other treatments. The PAE was augmented dependently on not only the concentration of H2O2 but the laser irradiation time. Electron spin resonance analysis showed that the hydroxyl radical was also generated dependently on both the concentration of H2O2 and the laser irradiation time, suggesting that the hydroxyl radicals contribute to the PAE. These results suggest that the disinfection treatment by photolysis of H2O2 induces PAE in S. aureus and S. salivarius even though they were treated for only 10-30 seconds.

本文言語English
ページ(範囲)92-100
ページ数9
ジャーナルJournal of Chemotherapy
26
2
DOI
出版ステータスPublished - 2014 4

ASJC Scopus subject areas

  • 腫瘍学
  • 薬理学
  • 薬理学(医学)
  • 感染症

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