Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype

Takamitsu Sasaki, Miho Horikawa, Kazuhiko Orikasa, Makoto Sato, Yoichi Arai, Yoshitaka Mitachi, Michinao Mizugaki, Masaaki Ishikawa, Masahiro Hiratsuka

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Cytochrome P450 4B1 (CYP4B1) is involved in the metabolism of several xenobiotics, such as 2-aminofluorene, 2-naphthylamine and benzidine. CYP4B1 allelic variants CYP4B1*1-*7 were recently identified. We thus hypothesized that CYP4B1 genotypes may modify bladder cancer risk. We examined the CYP4B1 genotypes in 169 bladder cancer cases and 190 hospital controls using a hybridization probe assay. Among the CYP4B1 genotypes observed, the most frequent genotypes in both the groups were CYP4B1*1/*1, *1/*2, *1/*3 and *2/*2. Logistic regression analysis revealed that the subjects carrying the CYP4B1*1/*2 or *2/*2 genotypes had a 1.75-fold increased risk of bladder cancer (95% CI=1.03-2.95, P = 0.038) compared with the subjects carrying the CYP4B1*1/*1 genotype. We demonstrated the first genetic study regarding the association of CYP4B1 with bladder cancer. Our results suggest that CYP4B1 genotypes might have an effect on the risk of bladder cancer.

本文言語English
ページ(範囲)634-640
ページ数7
ジャーナルJapanese journal of clinical oncology
38
9
DOI
出版ステータスPublished - 2008
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究

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