Possibility for tumor detection with fatty acid analogs

Kazuo Kubota; Toshihiro Takahashi; Takehiko Fujiwara; Susumu Yamada; Tachio Sato; Roko Kubota; Ren Iwata; Kiichi Ishiwata; Tatsuo Ido; Taiju Matsuzawa

doi:10.1016/0883-2897(91)90078-Y

Possibility for tumor detection with fatty acid analogs

Kazuo Kubota, Toshihiro Takahashi, Takehiko Fujiwara, Susumu Yamada, Tachio Sato, Roko Kubota, Ren Iwata, Kiichi Ishiwata, Tatsuo Ido, Taiju Matsuzawa

研究成果: Article › 査読

4 被引用数 (Scopus)

抄録

Newly synthesized 17-[¹⁸F]fluoro-3-methylheptadecanoic acid ([¹⁸F]BMHDA), 16-[¹⁸F]fluoropalmitic acid ([¹⁸F]PA) and 15-(p-[¹²⁵I]iodophenyl)-3-R,S-methylpentadecanoic acid ([¹²⁵I]BMIPP), fatty acid tracers, were examined for the possibility of tumor imaging using 10 tumor models in rats and mice. The highest tumor/muscle ratios with [¹⁸F]BMHDA were 2.3 using rat tumor AH109A and 1.9 using mouse tumor B16F1 (tumor accumulation 0.41 ± 0.05, 4.29 ± 0.77% ID/g, respectively). Tumor/muscle ratios with [¹²⁵I]BMIPP and [¹⁸F]PA were lower than those with [¹⁸F]BMHDA. Labeled fatty acids seem to have a lower potential for tumor detection.

本文言語	English
ページ（範囲）	191-195
ページ数	5
ジャーナル	International Journal of Radiation Applications and Instrumentation.
巻	18
号	2
DOI	https://doi.org/10.1016/0883-2897(91)90078-Y
出版ステータス	Published - 1991
外部発表	はい

ASJC Scopus subject areas

医学（全般）

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@article{22e21ea2e6c04236a7c21fb2cfb9dd5e,

title = "Possibility for tumor detection with fatty acid analogs",

abstract = "Newly synthesized 17-[18F]fluoro-3-methylheptadecanoic acid ([18F]BMHDA), 16-[18F]fluoropalmitic acid ([18F]PA) and 15-(p-[125I]iodophenyl)-3-R,S-methylpentadecanoic acid ([125I]BMIPP), fatty acid tracers, were examined for the possibility of tumor imaging using 10 tumor models in rats and mice. The highest tumor/muscle ratios with [18F]BMHDA were 2.3 using rat tumor AH109A and 1.9 using mouse tumor B16F1 (tumor accumulation 0.41 ± 0.05, 4.29 ± 0.77% ID/g, respectively). Tumor/muscle ratios with [125I]BMIPP and [18F]PA were lower than those with [18F]BMHDA. Labeled fatty acids seem to have a lower potential for tumor detection.",

author = "Kazuo Kubota and Toshihiro Takahashi and Takehiko Fujiwara and Susumu Yamada and Tachio Sato and Roko Kubota and Ren Iwata and Kiichi Ishiwata and Tatsuo Ido and Taiju Matsuzawa",

note = "Funding Information: Acknowledgements-The authorst hankt he Nihon Medi-Physics Co. Ltd for generouslys upplyingt he [{\textquoteleft}2SI]BMIPP for this study,M r Y. Sugawarafo r photographya, nd Miss A. Yamamoto for the illustrations.T his work was supported by a Grant-in-Aid for Cancer Researchf rom the Ministry of Education, Sciencea nd Culture, Japan, and from the Ministry of Health and Welfare,J apan.",

year = "1991",

doi = "10.1016/0883-2897(91)90078-Y",

language = "English",

volume = "18",

pages = "191--195",

journal = "International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology",

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T1 - Possibility for tumor detection with fatty acid analogs

AU - Kubota, Kazuo

AU - Takahashi, Toshihiro

AU - Fujiwara, Takehiko

AU - Yamada, Susumu

AU - Sato, Tachio

AU - Kubota, Roko

AU - Iwata, Ren

AU - Ishiwata, Kiichi

AU - Ido, Tatsuo

AU - Matsuzawa, Taiju

N1 - Funding Information: Acknowledgements-The authorst hankt he Nihon Medi-Physics Co. Ltd for generouslys upplyingt he [‘2SI]BMIPP for this study,M r Y. Sugawarafo r photographya, nd Miss A. Yamamoto for the illustrations.T his work was supported by a Grant-in-Aid for Cancer Researchf rom the Ministry of Education, Sciencea nd Culture, Japan, and from the Ministry of Health and Welfare,J apan.

PY - 1991

Y1 - 1991

N2 - Newly synthesized 17-[18F]fluoro-3-methylheptadecanoic acid ([18F]BMHDA), 16-[18F]fluoropalmitic acid ([18F]PA) and 15-(p-[125I]iodophenyl)-3-R,S-methylpentadecanoic acid ([125I]BMIPP), fatty acid tracers, were examined for the possibility of tumor imaging using 10 tumor models in rats and mice. The highest tumor/muscle ratios with [18F]BMHDA were 2.3 using rat tumor AH109A and 1.9 using mouse tumor B16F1 (tumor accumulation 0.41 ± 0.05, 4.29 ± 0.77% ID/g, respectively). Tumor/muscle ratios with [125I]BMIPP and [18F]PA were lower than those with [18F]BMHDA. Labeled fatty acids seem to have a lower potential for tumor detection.

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Possibility for tumor detection with fatty acid analogs

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