Porous poly (lactic-co-glycolide) microsphere sintered scaffolds for tissue repair applications

Yingjun Wang, Xuetao Shi, Li Ren, Chunming Wang, Dong An Wang

    研究成果: Article査読

    44 被引用数 (Scopus)

    抄録

    In this paper, a new route to preparing porous poly (lactic-co-glycolide) (PLGA) scaffolds for bone tissue repair applications was developed. Novel porous PLGA scaffolds were fabricated via microsphere sintered technique and gas forming technique. Ammonium bicarbonate was used to regulate porosity of these porous scaffolds. Porosity of the scaffolds, and cell attachment, viability and proliferation on the scaffolds were evaluated. The results indicated that PLGA porous scaffolds were with the porosity from around 30% to 95% by regulating ammonium bicarbonate content from 0 to 10%. We also found that PLGA porous microsphere scaffolds benefited cell attachment and viability. Taken together, the achieved porous scaffolds have controlled porosity and also support mesenchymal stem cell proliferation, which could serve as potential scaffolds for bone repair applications.

    本文言語English
    ページ(範囲)2502-2507
    ページ数6
    ジャーナルMaterials Science and Engineering C
    29
    8
    DOI
    出版ステータスPublished - 2009 10 15

    ASJC Scopus subject areas

    • 材料科学(全般)
    • 凝縮系物理学
    • 材料力学
    • 機械工学

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