Polysaccharide (ank-102) from polianthes tuberosa cells deteriorates the resistance of mice to listeria monocytogenes infection

Toshiro Majima, Kazuya Otsuji, Ryoichi Nagatomi, Tasuke Konno

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, an intracellular gram-positive bacterium eliminated mainly by macrophages through T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy 1.2 expression on the surface of the thymocytes. A new type of immunosuppressive polysaccharide ANK-102 was introduced.

本文言語English
ページ(範囲)59-68
ページ数10
ジャーナルImmunopharmacology and Immunotoxicology
17
1
DOI
出版ステータスPublished - 1995 1月 1
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 毒物学
  • 薬理学

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