Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice

Kenta Teruya; Ayumi Oguma; Keita Arai; Keiko Nishizawa; Sara Iwabuchi; Miki Watanabe-Matsui; Yuji Sakasegawa; Hermann Schätzl; Sabine Gilch; Katsumi Doh-ura

doi:10.1016/j.bbrc.2021.04.116

Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice

Kenta Teruya, Ayumi Oguma, Keita Arai, Keiko Nishizawa, Sara Iwabuchi, Miki Watanabe-Matsui, Yuji Sakasegawa, Hermann Schätzl, Sabine Gilch, Katsumi Doh-ura

医学系研究科・附属創生応用医学研究センター

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness.

本文言語	English
ページ（範囲）	105-111
ページ数	7
ジャーナル	Biochemical and biophysical research communications
巻	560
DOI	https://doi.org/10.1016/j.bbrc.2021.04.116
出版ステータス	Published - 2021 6月 30

ASJC Scopus subject areas

生物理学
生化学
分子生物学
細胞生物学

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10.1016/j.bbrc.2021.04.116

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Teruya, K., Oguma, A., Arai, K., Nishizawa, K., Iwabuchi, S., Watanabe-Matsui, M., Sakasegawa, Y., Schätzl, H., Gilch, S., & Doh-ura, K. (2021). Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice. Biochemical and biophysical research communications, 560, 105-111. https://doi.org/10.1016/j.bbrc.2021.04.116

Teruya, K, Oguma, A, Arai, K, Nishizawa, K, Iwabuchi, S, Watanabe-Matsui, M, Sakasegawa, Y, Schätzl, H, Gilch, S & Doh-ura, K 2021, 'Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice', Biochemical and biophysical research communications, vol. 560, pp. 105-111. https://doi.org/10.1016/j.bbrc.2021.04.116

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title = "Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice",

abstract = "Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness.",

keywords = "Cellulose ether, Genetic analysis, Glia maturation factor, Prion, Proportional hazards model, Proteomics",

author = "Kenta Teruya and Ayumi Oguma and Keita Arai and Keiko Nishizawa and Sara Iwabuchi and Miki Watanabe-Matsui and Yuji Sakasegawa and Hermann Sch{\"a}tzl and Sabine Gilch and Katsumi Doh-ura",

note = "Funding Information: This work was supported by grants from the Japan Society for the Promotion of Science [ 19K22479 (KT) and 19H03570 (KD)], and the Alberta Prion Research Institute Program [ 201700012 (SG, HS, KD)]. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

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doi = "10.1016/j.bbrc.2021.04.116",

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AU - Teruya, Kenta

AU - Oguma, Ayumi

AU - Arai, Keita

AU - Nishizawa, Keiko

AU - Iwabuchi, Sara

AU - Watanabe-Matsui, Miki

AU - Sakasegawa, Yuji

AU - Schätzl, Hermann

AU - Gilch, Sabine

AU - Doh-ura, Katsumi

N1 - Funding Information: This work was supported by grants from the Japan Society for the Promotion of Science [ 19K22479 (KT) and 19H03570 (KD)], and the Alberta Prion Research Institute Program [ 201700012 (SG, HS, KD)]. Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/6/30

Y1 - 2021/6/30

N2 - Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness.

AB - Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness.

KW - Cellulose ether

KW - Genetic analysis

KW - Glia maturation factor

KW - Prion

KW - Proportional hazards model

KW - Proteomics

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Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice

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