Polymorphisms in glia maturation factor β gene are markers of cellulose ether effectiveness in prion-infected mice

Kenta Teruya, Ayumi Oguma, Keita Arai, Keiko Nishizawa, Sara Iwabuchi, Miki Watanabe-Matsui, Yuji Sakasegawa, Hermann Schätzl, Sabine Gilch, Katsumi Doh-ura

研究成果: Article査読

抄録

Anti-prion effects of cellulose ether (CE) are reported in rodents, but the molecular mechanism is fully unknown. Here, we investigated the genetic background of CE effectiveness by proteomic and genetic analysis in mice. Proteomic analysis in the two mouse lines showing a dramatic difference in CE effectiveness revealed a distinct polymorphism in the glia maturation factor β gene. This polymorphism was significantly associated with the CE effectiveness in various prion-infected mouse lines. Sequencing of this gene and its vicinity genes also revealed several other polymorphisms that were significantly related to the CE effectiveness. These polymorphisms are useful as genetic markers for finding more suitable mouse lines and exploring the genetic factors of CE effectiveness.

本文言語English
ページ(範囲)105-111
ページ数7
ジャーナルBiochemical and biophysical research communications
560
DOI
出版ステータスPublished - 2021 6 30

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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