Polymers of 2-methacryloyloxyethyl phosphorylcholine truly work as cell membrane mimic?

Tomoko Mori, Takuya Kubo, Toyohiko J. Konno, Ken Hosoya

研究成果: Article査読

2 被引用数 (Scopus)

抄録

We have prepared several types of polymers derived from 2-methacryloyloxyethyl phosphorylcholine (MPC) to evaluate whether polymers of MPC work as cell membrane mimic or not. We firstly applied capturing test of target proteins of 4-carboxybenzenesulfonamide (Sul) or ibuprofen (Ibu) as a probe.As the results, the rather hydrophilic polymers based on MPC were able to suppress non-specific binding proteins as expected. Additionally, some of the MPC based polymeric surface was able to capture greater amount of carbonic anhydrase II than those of other polymers, when Sul was utilized as probe. In contrary, all the polymers having PC groups and Ibu probe were unable to capture Cyclooxygenase-1 (COX-1), its target protein. These results suggested that the position of PC groups realized hydrophilic polymer surface, while MPC based polymer was not able to supply the suitable environment for COX-1 to interact with Ibu.

本文言語English
ページ(範囲)181-186
ページ数6
ジャーナルColloids and Surfaces B: Biointerfaces
84
1
DOI
出版ステータスPublished - 2011 5 1

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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