Polyamine homeostasis in plants: The role(s) of evolutionarily conserved upstream ORFs

Sunil Kumar Thalor, Thomas Berberich, Tomonobu Kusano

    研究成果: Chapter

    1 被引用数 (Scopus)


    Cellular polyamine (PA) concentrations are strictly controlled by complex regulatory processes that occur during the synthesis, catabolism, and transport of this compound. These processes include translational repression mediated by upstream open reading frames (uORFs) found in the mRNAs of genes involved in PA metabolism. First, we discuss the roles of dual uORFs in the S -adenosylmethionine decarboxylase gene. Second, we summarize the role of the fourth uORF in a basic helix-loop-helix transcription factor gene, SAC51, in thermospermine action in terms of its effect on xylem vessel differentiation and stem growth. Third, we discuss the sequence-conserved uORFs found in polyamine oxidase (PAO) transcripts encoding peroxisome-localized PAOs. It is currently unclear whether these uORFs cause the repression of PAO translation. Finally, because uORF-mediated repression of arginine decarboxylase (ADC) translation was reported in carnation, we critically assess the role of uORF in ADC translation.

    ホスト出版物のサブタイトルA Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism
    出版社Springer Japan
    出版ステータスPublished - 2015 1月 1

    ASJC Scopus subject areas

    • 生化学、遺伝学、分子生物学(全般)
    • 医学(全般)


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