Poly lactic acid-caprolactone copolymer tube with a denatured skeletal muscle segment inside as a guide for peripheral nerve regeneration: A morphological and electrophysiological evaluation of the regenerated nerves

Nurru L. Mligiliche, Yasuhiko Tabata, Masaaki Kitada, Katsuaki Endoh, Keiko Okamato, Etsuko Fujimoto, Chizuka Ide

研究成果: Article査読

37 被引用数 (Scopus)

抄録

A biodegradable copolymer of poly L-lactic acid and E-caprolactone (PLAC) was manufactured into a tube, in which a denatured skeletal muscle segment was placed longitudinally. This model tube was implanted as a guide to promote nerve regeneration across a 5 cm gap in the rabbit sciatic nerve. Five months after implantation, good nerve regeneration was found throughout the graft and in the distal host nerve. The population (29.6/16 × 102 μm2) of regenerated nerves in the graft was higher than that of the contralateral normal sciatic nerve (18.0/16 × 102 μm2). Regenerated nerve fibers extended to the distal host nerve. The number of myelinated fibers was 13.7/16 × 102 μm2 at a level 1.5 cm from the distal suture. The diameters (below 2 μm) of most regenerated myelinated nerves in the graft and in the distal host nerve were much smaller than those (6-8 μm) of normal nerves. Electrophysiological evaluation showed that the hindlimb muscle (gastrocnemius) was innervated by motor nerves in all animals 5 months after implantation. These results indicate that the PLAC tube with a denatured muscle segment inside provided good conditions for nerve fiber regrowth. The PLAC tube is thought to protect the denatured muscle segment from rapid dissociation in the host tissue.

本文言語English
ページ(範囲)156-161
ページ数6
ジャーナルAnatomical Science International
78
3
DOI
出版ステータスPublished - 2003 9

ASJC Scopus subject areas

  • 解剖学

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