Podoplanin expression in primary central nervous system germ cell tumors: A useful histological marker for the diagnosis of germinoma

Kazuhiko Mishima, Yukinari Kato, Mika K. Kaneko, Youya Nakazawa, Akiko Kunita, Naoya Fujita, Takashi Tsuruo, Ryo Nishikawa, Takanori Hirose, Masao Matsutani

研究成果: Article査読

118 被引用数 (Scopus)

抄録

Podoplanin, a mucin-like transmembrane sialoglycoprotein, promotes platelet aggregation and may be involved in cancer cell migration, invasion, metastasis, and malignant progression. Podoplanin/aggrus is highly expressed in testicular seminoma, suggesting that it may be a sensitive marker for testicular seminomas. Here we investigated the expression of podoplanin in central nervous system (CNS) germ cell tumors (GCTs) by immunohistochemical staining of tumor samples from 62 patients. In 40 of 41 (98%) germinomas (including germinomatous components in mixed GCTs), podoplanin was diffusely expressed on the surface of germinoma cells; lymphocytes, interstitial cells, and syncytiotrophoblastic giant cells were negative for podoplanin. Except for immature teratomas (12/17; 71%), podoplanin expression was absent in non-germinomatous GCTs, including seven teratomas, seven embryonal carcinomas, seven yolk sac tumors, and seven choriocarcinomas. In immature teratomas, focal podoplanin staining was observed in fewer than 10% of immature squamous and columnar epithelial cells. Thus, podoplanin expression may be a sensitive immunohistochemical marker for germinoma in CNS GCTs. As such, it may be useful for diagnosis, for monitoring the efficacy of treatment, and as a potential target for antibody-based therapy.

本文言語English
ページ(範囲)563-568
ページ数6
ジャーナルActa neuropathologica
111
6
DOI
出版ステータスPublished - 2006 6月
外部発表はい

ASJC Scopus subject areas

  • 病理学および法医学
  • 臨床神経学
  • 細胞および分子神経科学

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