PMab-241 specifically detects bear podoplanin of lymphatic endothelial cells in the lung of brown bear

Junko Takei, Shinji Yamada, Satoru Konnai, Tsuyoshi Ishinazaka, Michito Shimozuru, Mika K. Kaneko, Yukinari Kato

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Podoplanin (PDPN)/T1alpha is utilized as a specific marker of lymphatic endothelial cells or type I alveolar cells of lung. Therefore, sensitive and specific monoclonal antibodies (mAbs) detecting PDPN are necessary for immunohistochemical analyses, especially using formalin-fixed paraffin-embedded tissues. Recently, we developed an anti-bear PDPN (bPDPN) mAb, PMab-247, which is useful for immunohistochemical analyses to detect both lymphatic endothelial cells and type I alveolar cells of lung. However, it is difficult to distinguish lymphatic endothelial cells from type I alveolar cells in the bear lung. In this study, we showed that a novel anti-bPDPN mAb, PMab-241 stained only lymphatic endothelial cells, not type I alveolar cells of the lung in immunohistochemical analyses. These findings suggest that PMab-241 could be useful for staining lymphatic endothelial cells specifically in the bear lung tissues.

本文言語English
ページ(範囲)282-284
ページ数3
ジャーナルMonoclonal antibodies in immunodiagnosis and immunotherapy
38
6
DOI
出版ステータスPublished - 2019 12

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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