Pleomorphic carcinoma of the lung associated with loss of heterozygosity of p53 gene

Norimasa Arita, Yoshiki Mikami, Minako Yoshida, Ichiro Konishi, Norio Horiike, Katsutoshi Miyauchi, Tatsuhiko Miyazaki, Masato Nose, Masao Ono

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We report a case with pleomorphic carcinoma of the lung in a 70-year-old man. Pleomorphic carcinoma is characterized by a heterogenous composition that includes epithelial and mesechymal malignancies. In the present case, the tumor was composed of a mixture of unequivocal squamous cell carcinoma and spindle cell components resembling sarcomatous overgrowth. The spindle component did not include a heterologous mesenchymal element characterized by overt differetiation for bone, cartilage, neuron or muscle tissue. To evaluate a state of differentiation of the spindle cell component, we immunohistochemically examined expression of the antigens including vimentin, cytokeratin, sarcomeric actin, α-smooth muscle actin, S-100 protein, CD34, Factor VIII, and CD68. The results showed sole expression of vimentin in the spindle cell component, suggesting an immature state of the mesenchymal lineage. Furthermore, the spindle cell component of this case was genetically characterized by loss of heterozygosity (LOH) at a codon 234 of exon 7 of the p53 gene. This mutation causes an amino-acid replacement (Tyr to Cys), which was previously proven to attenuate p53 function. The present case may suggest a relation between somatic alteration of the p53 gene and histogenesis of pleomorphic carcinoma.

本文言語English
ページ(範囲)181-185
ページ数5
ジャーナルTohoku Journal of Experimental Medicine
206
2
DOI
出版ステータスPublished - 2005 6

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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