Platinum-catalyzed dehydroalkoxylation-cyclization cascade via N-O bond cleavage

研究成果: Article査読

51 被引用数 (Scopus)

抄録

ortho-Alkynylphenylureas and -acetamides 1, with an alkoxy and aryl group on the nitrogen atom, were subjected to platinum-catalyzed cyclization reactions to afford the corresponding tetracyclic compounds 2, via N-O bond cleavage, in good to excellent yields. For example, N-methoxy-N′-methyl-N′-(2- (pent-1-ynyl)phenyl)-N-phenylurea (1a) was reacted for 12 h in the presence of PtI4 (10 mol%) in 1,4-dioxane at 100 Celsius to afford 5-methyl-12-propylindolo[1,2-c]quinazolin-6(5H)-one (2a) in 93% yield, via an iminium-bound platinum carbenoid intermediate, followed by an aromatic C-H insertion.

本文言語English
ページ(範囲)4198-4199
ページ数2
ジャーナルJournal of the American Chemical Society
131
12
DOI
出版ステータスPublished - 2009 4 1

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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