Plasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions: The Ohasama study

Yoko Aono, Takayoshi Ohkubo, Masahiro Kikuya, Azusa Hara, Takeo Kondo, Taku Obara, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Yoriko Shintani, Junichiro Hashimoto, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Shin Ichi Izumi, Yutaka Imai

研究成果: Article査読

46 被引用数 (Scopus)

抄録

OBJECTIVE - Twenty-four-hour ambulatory blood pressure (24-hour ABP) values are considered a powerful predictor of stroke. Silent cerebrovascular lesions are associated with an increased risk of stroke. Because fibrinogen is a major determinant of plasma viscosity, an elevated fibrinogen level might also be associated with stroke risk. We evaluated the association of 24-hour ABP and plasma fibrinogen levels with the risk of silent cerebrovascular lesions (white matter hyperintensity and lacunar infarct) detected by MRI. METHODS AND RESULTS - The study cohort comprised 958 individuals from the general population of Ohasama, a rural Japanese community. Multiple logistic regression analysis adjusted for age, sex, smoking and drinking status, use of antihypertensive medication, body mass index, 24-hour ABP, and a history of hypercholesterolemia, diabetes mellitus, and atrial fibrillation demonstrated that each 1-SD increase in fibrinogen level was associated with a significantly increased risk of silent cerebrovascular lesions (odds ratio, 1.26; P=0.001). The 24-hour ABP was also significantly and independently associated with the risk of silent cerebrovascular lesions. Even when 24-hour ABP values were within normal range (<135/80 mm Hg), elevated fibrinogen levels were associated with an increased risk of silent cerebrovascular lesions. Fibrinogen and 24-hour BP had additive effects on silent cerebrovascular lesions. CONCLUSION - The 24-hour ABP and plasma fibrinogen levels were closely and independently associated with the risk of silent cerebrovascular lesions including white matter hyperintensity and lacunar infarct.

本文言語English
ページ(範囲)963-968
ページ数6
ジャーナルArteriosclerosis, thrombosis, and vascular biology
27
4
DOI
出版ステータスPublished - 2007 4月

ASJC Scopus subject areas

  • 循環器および心血管医学

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