Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae)1

Sui‐Ming ‐M Wong, Yoshiteru Oshima, John M. Pezzuto, Harry H.S. Fong, Norman R. Farnsworth

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Employing the roots of Iris missouriensis, two known triterpenes, iso‐iridogermanal and zeorin, were isolated and identified. As presently reported, they were found to demonstrate cytotoxic activity toward cultured P‐388 cells (ED50 = 0.1 and 1.1 μg/mL, respectively). Additionally, a new triterpene that demonstrated an ED50 of 8.5 μg/mL was isolated. On the basis of spectral analysis and chemical correlation with zeorin, the structure was shown to be 6α‐hydroxy‐A'‐neogermmacer‐22(29)‐en‐30‐oic acid (missourin).

本文言語English
ページ(範囲)317-320
ページ数4
ジャーナルJournal of Pharmaceutical Sciences
75
3
DOI
出版ステータスPublished - 1986 3

ASJC Scopus subject areas

  • Pharmaceutical Science

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