TY - JOUR
T1 - Planar polarized contractile actomyosin networks in dynamic tissue morphogenesis
AU - Umetsu, Daiki
AU - Kuranaga, Erina
N1 - Funding Information:
This work was supported by grants from MEXT KAKENHI Grant Number JP26114003 (E.K.) and the JSPS KAKENHI Grant Number 15K18536 (D.U.), JP24687027 (E.K.), JP16H04800 (E.K.), and grants from the Uehara Memorial Foundation, the Kanae Foundation for the Promotion of Medical Science, the Takeda Science Foundation and the Mitsubishi Foundation to EK.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/8/1
Y1 - 2017/8/1
N2 - The complex shapes of animal bodies are constructed through a sequence of simple physical interactions of constituent cells. Mechanical forces generated by cellular activities, such as division, death, shape change and rearrangement, drive tissue morphogenesis. By confining assembly or disassembly of actomyosin networks within the three-dimensional space of the cell, cells can localize forces to induce tissue deformation. Tissue-scale morphogenesis emerges from a collective behavior of cells that coordinates the force generation in space and time. Thus, the molecular mechanisms that govern the temporal and spatial regulation of forces in individual cells are elemental to organogenesis, and the tissue-scale coordination of forces generated by individual cells is key to determining the final shape of organs.
AB - The complex shapes of animal bodies are constructed through a sequence of simple physical interactions of constituent cells. Mechanical forces generated by cellular activities, such as division, death, shape change and rearrangement, drive tissue morphogenesis. By confining assembly or disassembly of actomyosin networks within the three-dimensional space of the cell, cells can localize forces to induce tissue deformation. Tissue-scale morphogenesis emerges from a collective behavior of cells that coordinates the force generation in space and time. Thus, the molecular mechanisms that govern the temporal and spatial regulation of forces in individual cells are elemental to organogenesis, and the tissue-scale coordination of forces generated by individual cells is key to determining the final shape of organs.
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U2 - 10.1016/j.gde.2017.03.012
DO - 10.1016/j.gde.2017.03.012
M3 - Review article
C2 - 28419933
AN - SCOPUS:85017537689
VL - 45
SP - 90
EP - 96
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
SN - 0959-437X
ER -