Pivalophenone imine as a benzonitrile surrogate for directed C-H bond functionalization

Wengang Xu, Naohiko Yoshikai

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Pivalophenone N-H imine has been found to serve as a prominent substrate for directed C-H alkylation and arylation reactions with alkyl bromides and aryl chlorides, respectively, under cobalt-N-heterocyclic carbene (NHC) catalysis. Unlike the case of the parent pivalophenone imine, the increased steric bulk of the resulting ortho-substituted pivalophenone imines allows them to undergo clean imine-to-nitrile conversion under peroxide photolysis or aerobic copper catalysis conditions. Overall, these two-step transformations offer convenient synthetic methods for ortho-functionalized benzonitriles.

本文言語English
ページ(範囲)5299-5304
ページ数6
ジャーナルChemical Science
8
8
DOI
出版ステータスPublished - 2017
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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