Pitx2 determines left-right asymmetry of internal organs in vertebrates

Aimee K. Ryan, Bruce Blumberg, Concepción Rodriguez-Esteban, Sayuri Yonei-Tamura, Koji Tamura, Tohru Tsukui, Jennifer De La Peña, Walid Sabbagh, Jason Greenwald, Senyon Choe, Dominic P. Norris, Elizabeth J. Robertson, Ronald M. Evans, Michael G. Rosenfeld, Juan Carlos Izpisúa Belmonte

研究成果: Article査読

414 被引用数 (Scopus)

抄録

The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin. The gene Pitx2 is expressed in the left lateral plate mesoderm and, subsequently, in the left heart and gut of mouse, chick and Xenopus embryos. Misexpression of Shh and Nodal induces Pitx2 expression, whereas inhibition of activin signalling blocks it. Misexpression of Pitx2 alters the relative position of organs and the direction of body rotation in chick and Xenopus embryos. Changes in Pitx2 expression are evident in mouse mutants with laterality defects. Thus, Pitx2 seems to serve as a critical downstream transcription target that mediates left-right asymmetry in vertebrates.

本文言語English
ページ(範囲)545-551
ページ数7
ジャーナルNature
394
6693
DOI
出版ステータスPublished - 1998 8 6
外部発表はい

ASJC Scopus subject areas

  • 一般

フィンガープリント

「Pitx2 determines left-right asymmetry of internal organs in vertebrates」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル