Photophysicochemical properties and TD-DFT calculations of a novel terminal alkyne substituted metal free phthalocyanine

Yusuf Yilmaz, John Mack, Mehmet Sönmez, Tebello Nyokong

研究成果: Article査読

1 被引用数 (Scopus)

抄録

The synthesis of a novel free base tetrakis(prop-2-ynyloxy)phthalocyanine (2) is described, along with its characterization by IR, UV-visible absorption, and 1H NMR spectroscopy and mass spectrometry. The compound exhibited good solubility in a wide range of organic solvents and no significant aggregation was observed over a wide concentration range. The values for the singlet oxygen (ΦΔ), photodegradation, fluorescence (ΦF) and triplet state quantum yields and the fluorescence and triplet state lifetimes are reported. A relatively high ΦΔ value of 0.46 was obtained in DMSO. The ability to carry out "click" chemistry at the ligand periphery enhances the potential utility of 2 for use in bioconjugates in photodynamic therapy (PDT). A moderately high ΦF value of 0.18 is observed for emission in the therapeutic window in the near-IR region, which suggests that it may also be possible to determine the level of localization of 2 in tumor cells through bioimaging.

本文言語English
ページ(範囲)251-258
ページ数8
ジャーナルJournal of Porphyrins and Phthalocyanines
18
3
DOI
出版ステータスPublished - 2014 3

ASJC Scopus subject areas

  • 化学 (全般)

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