Photocontrol of Polypeptide Helix Sense by Cis-Trans Isomerism of Side-Chain Azobenzene Moieties

Akihiko Ueno, Keiko Takahashi, Jun ichi Anzai, Tetsuo Osa

研究成果: Article査読

115 被引用数 (Scopus)

抄録

The effect of light on polypeptide conformation was investigated by circular dichroism measurements on a series of copolymers composed of β-benzyl L-aspartate and β-(m-phenylazo)benzyl L-aspartate, dissolved in the mixed solvents of 1,2-dichloroethane (DCE) and trimethyl phosphate (TMP). The dark-adapted (trans) copolymers are all left-handed helices in DCE and undergo a conformational change from a left-handed helix to a right-handed helix with an increase in the amount of TMP in the solutions. Photoisomerization of the side-chain azobenzene moieties from trans to cis isomers also causes helix reversal in these copolymers at adequate solvent compositions. These copolymers exhibit CD bands in the regions of azobenzene n-π* and π-π* transitions which change their CD signs corresponding to the helix reversal.

本文言語English
ページ(範囲)6410-6415
ページ数6
ジャーナルJournal of the American Chemical Society
103
21
DOI
出版ステータスPublished - 1981 10

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

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