Photo-enhanced Aqueous Solubilization of an Azo-compound

Minoru Ishikawa, Takuya Ohzono, Takao Yamaguchi, Yasuo Norikane

研究成果: Article査読

10 被引用数 (Scopus)

抄録

We previously showed that disruption of intermolecular interactions, e.g., by lowering the molecular planarity and/or introducing bent structures, improves the aqueous solubility of compounds, and based upon that work, we hypothesized that azobenzene trans-to-cis photoswitching could also be utilized to enhance the aqueous solubility of compounds. Here, we demonstrate that UV/visible light irradiation can reversibly switch the aqueous solubilization of an anti-cancer candidate drug, a low-molecular-weight kinase inhibitor bearing an azobenzene moiety. The increase of solubilization associated with UV-induced trans-to-cis conversion may have clinical relevance, because the time-scale of thermal cis-to-trans reversion at 37 °C is longer than that of oral absorption.

本文言語English
論文番号6909
ジャーナルScientific reports
7
1
DOI
出版ステータスPublished - 2017 12 1
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ASJC Scopus subject areas

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