Photo-cross-linked small-molecule affinity matrix as a tool for target identification of bioactive small molecules

Naoki Kanoh

研究成果: Review article査読

17 被引用数 (Scopus)

抄録

Covering: up to the end of 2015 A photo-cross-linked small-molecule affinity matrix is a unique platform for identifying targets for bioactive small molecules. It utilises a photogenerated carbene species to immobilise a variety of bioactive small molecules on an affinity matrix in a chemo- and site-nonselective manner. Although this platform would seem to run counter to the more typical approach of small-molecule immobilisation on an affinity matrix (i.e., selective coupling), it has been successfully utilised in the past decade to screen protein targets for many bioactive small molecules. This review describes the status of the photo-cross-linking methodology while providing a useful tutorial for academic and industrial chemical biologists who are involved or interested in drug target identification.

本文言語English
ページ(範囲)709-718
ページ数10
ジャーナルNatural Product Reports
33
5
DOI
出版ステータスPublished - 2016 5

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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