Phosphorylation and activation of calmodulin-sensitive cyclic nucleotide phosphodiesterase by a brain Ca2+, calmodulin-dependent protein kinase

Kohji Fukunaga, Hideyuki Yamamoto, Etsuro Tanaka, Takafumi Iwasa, Eishichi Miyamoto

研究成果: Article

13 引用 (Scopus)

抜粋

A Ca2+, calmodulin-dependent protein kinase from rat brain with a MW of 640,000 phosphorylated calmodulin-sensitive phosphodiesterase from the brain cytosol. The Km of the enzyme for the phosphodiesterase was 5.0 μM and the Vmax was 212 nmol/mg/min. The amount of phosphate incorporated into the phosphodiesterase was 0.7 mol/mol subunit. Phosphorylation of the phosphodiesterase enhanced the enzyme activity by about 20% for hydrolysis of a higher concentration of cyclic AMP.

元の言語English
ページ(範囲)493-499
ページ数7
ジャーナルLife Sciences
35
発行部数5
DOI
出版物ステータスPublished - 1984 7 30
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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