@article{1ef2a044faaa4cc8b1c1b8b70ad42261,
title = "Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2",
abstract = "Osawa et al. find that accumulation of phosphoethanolamine (PEtn) protects cancer cells under glutamine starvation through the downregulation of PCYT2. Glutamine regulates PE biosynthesis through PCYT2, resulting in pro-tumorigenic metabolite PEtn accumulation. PEtn stimulates the tolerance of cancer cells to starvation, and lowered PCYT2 expression correlates with decreased survival in patients.",
keywords = "PCYT2, PE biosynthesis, amino acids, cancer metabolism, glutamine deprivation, hypoxia, nutrient starvation, phosphoethanolamine, tumor microenvironments",
author = "Tsuyoshi Osawa and Teppei Shimamura and Kyoko Saito and Yoko Hasegawa and Naoko Ishii and Miyuki Nishida and Ritsuko Ando and Ayano Kondo and Muyassar Anwar and Rika Tsuchida and Shinjiro Hino and Akihisa Sakamoto and Kaori Igarashi and Kaori Saitoh and Keiko Kato and Keiko Endo and Shotaro Yamano and Yasuharu Kanki and Yoshihiro Matsumura and Takashi Minami and Toshiya Tanaka and Motonobu Anai and Youichiro Wada and Hideki Wanibuchi and Mitsuhiro Hayashi and Akinobu Hamada and Masayuki Yoshida and Shinichi Yachida and Mitsuyoshi Nakao and Juro Sakai and Hiroyuki Aburatani and Masabumi Shibuya and Kentaro Hanada and Satoru Miyano and Tomoyoshi Soga and Tatsuhiko Kodama",
note = "Funding Information: We thank the members of the Laboratory for Systems Biology and Medicine and Integrative Nutriomics and Oncology, RCAST, The University of Tokyo. We especially thank Ms. A. Izumi, Dr. G. Nagae (RCAST, The University of Tokyo), Dr. S. Ishikawa (Tokyo Dental and Medical University), Dr. A. Hirao (Kanazawa University), and Dr. S. Kuroda (The University of Tokyo) for helpful discussions. The super-computing resource was provided by the Human Genome Center (The University of Tokyo). This work was supported by a Grant-in-Aid for Young Scientists (A) ( 26710005 , T.O.; 15H05325 , T. Shimamura), a Grant-in-Aid for Scientific Research (B) ( 19H03496 , T.O.), a Grant-in-Aid on Innovative Areas ( 16H01567 , 18H04797 , and 18H04897 , T.O.; 15H05912 , T. Shimamura and S.M.), and a Grant-in-Aid for Challenging Exploratory Research ( 16K14605 and 19K22553 , T.O.; 15K12139 , T. Shimamura) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, Priority Issue on Post-K Computer, Integrated Computational Life Science to Support Personalized and Preventive Medicine ( hp170227 , S.M.); JSPS KAKENHI ( JP16H06276 , H.W.); Takeda Science Foundation (T.O.); Kobayashi Foundation for Cancer Research (T.O.); MSD Life Science Foundation (T.O.); Project for Cancer Research and Therapeutic Evolution (P-CREAT); Practical Research for Innovative Cancer Control ( 16cm0106223h0001 , M.H., H.A., T.K., and T.O.) from the Japan Agency for Medical Research and Development (AMED) (T.K., H.A., and T.O.); Research on Regulatory Science of Pharmaceuticals and Medical Devices ( 18mk0101127h0001 , M.H.); and the AMED-CREST from the AMED (T. Soga; JP18gm0910005j0004 , K.H.). Funding Information: We thank the members of the Laboratory for Systems Biology and Medicine and Integrative Nutriomics and Oncology, RCAST, The University of Tokyo. We especially thank Ms. A. Izumi, Dr. G. Nagae (RCAST, The University of Tokyo), Dr. S. Ishikawa (Tokyo Dental and Medical University), Dr. A. Hirao (Kanazawa University), and Dr. S. Kuroda (The University of Tokyo) for helpful discussions. The super-computing resource was provided by the Human Genome Center (The University of Tokyo). This work was supported by a Grant-in-Aid for Young Scientists (A) (26710005, T.O.; 15H05325, T. Shimamura), a Grant-in-Aid for Scientific Research (B) (19H03496, T.O.), a Grant-in-Aid on Innovative Areas (16H01567, 18H04797, and 18H04897, T.O.; 15H05912, T. Shimamura and S.M.), and a Grant-in-Aid for Challenging Exploratory Research (16K14605 and 19K22553, T.O.; 15K12139, T. Shimamura) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, Priority Issue on Post-K Computer, Integrated Computational Life Science to Support Personalized and Preventive Medicine (hp170227, S.M.); JSPS KAKENHI (JP16H06276, H.W.); Takeda Science Foundation (T.O.); Kobayashi Foundation for Cancer Research (T.O.); MSD Life Science Foundation (T.O.); Project for Cancer Research and Therapeutic Evolution (P-CREAT); Practical Research for Innovative Cancer Control (16cm0106223h0001, M.H. H.A. T.K. and T.O.) from the Japan Agency for Medical Research and Development (AMED) (T.K. H.A. and T.O.); Research on Regulatory Science of Pharmaceuticals and Medical Devices (18mk0101127h0001, M.H.); and the AMED-CREST from the AMED (T. Soga; JP18gm0910005j0004, K.H.). T.O. and T.K. designed the experiments; T.O. T. Shimamura, K. Saito, Y.H. N.I. M. Nishida, A.K. M. Anwar, R.T. A.S. K.I. K. Saitoh, K.K. K.E. S. Yamano, M. Anai, M.H. and M.Y. performed the experiments; T.O. T. Shimamura, S.H. Y.K. Y.M. T.M. T.T. Y.W. H.W. A.H. S. Yachida, M. Nakao, J.S. H.A. M.S. K.H. S.M. T. Soga, and T.K. analyzed and interpreted the data; T.O. wrote the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = oct,
day = "1",
doi = "10.1016/j.celrep.2019.08.087",
language = "English",
volume = "29",
pages = "89--103.e7",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}
